![]() Porphyrins absorb light at around 420nm and interact with molecular triplet oxygen to form radicals and reactive oxygen species (ROS) that lead to cell death. This membrane has two chromophores, one of which is porphyrin. ATP production requires integrity of the mitochondrial inner membrane, which is where respiratory complexes are located. They have optical characteristics and absorb short wavelength light that is regarded as harmful and is associated with reduced function. Mitochondria provide much of the energy for cell function in the form of ATP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript.įunding: GJ Biotechnology and Biological Sciences Research Council BB/N000250/1. Received: ApAccepted: AugPublished: September 3, 2021Ĭopyright: © 2021 Kam et al. Skoulakis, Biomedical Sciences Research Center Alexander Fleming, GREECE Hence, the effect of short wavelengths on mitochondrial function is to reduce complex activity and increasing membrane permeability, but light exposure to reduce ATP and to translate into reduced mobility needs to be sustained.Ĭitation: Kam JH, Hogg C, Fosbury R, Shinhmar H, Jeffery G (2021) Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility. However, despite this, normal mobility did not return. ATP and mitochondrial membrane permeability recovered and over corrected at 72h post exposure. There are multiple options for energy/time exposure combinations, but we then applied single 420nm exposure of 3h to increase the probability of an effect on ATP and mobility, and both were significantly reduced. Adenosine triphosphate (ATP) levels were not significantly reduced and mobility was unchanged. Daily 15 mins exposures for a week significantly reduced mitochondrial complex activities and increased mitochondrial inner membrane permeability, which is a key metric of mitochondrial health. ![]() We examine the impact of 420nm exposure on drosophila melanogaster mitochondria and its impact on fly mobility. This 420nm absorption is probably due to the presence of porphyrin. Mitochondria absorb short wavelength light but have a specific absorbance at 420nm at the lower end of the human visual range. Increased blue light exposure has become a matter of concern as it has a range of detrimental effects, but the mechanisms remain unclear.
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